Do you know that coronary heart illness and osteoporosis are carefully linked — to such an extent that it’s been instructed these with coronary heart illness ought to be screened for osteoporosis and vice versa? In keeping with rising science, the 2 situations are tied collectively by one main issue— irritation.
In order that’s why, for February Coronary heart Well being Month, I’m recommending you receive one easy blood take a look at that’s able to detecting runaway irritation and its associated antioxidant deficit—the C-Reactive Protein (CRP) take a look at. In actual fact, some authorities recommend that the high-sensitivity CRP take a look at may predict the chance of growing severe coronary heart illness (and different power sicknesses) years upfront (He et al. 2010; Li et al. 2017).
What’s C-reactive protein?
C-Reactive Protein (CRP) is produced within the liver in response to irritation; its job within the physique is to connect itself to phosphocholine (a chemical produced by each microbes and cells which are dying) to “flag” the undesirable cells for the immune system to take away.
If there’s an precise an infection or damage current, irritation and the ensuing excessive CRP aren’t such a foul factor — you need your immune system to be activated so it might probably discover and get rid of micro organism or lifeless and injured tissue — however in coronary heart illness and different power sicknesses, the excessive stage of CRP alerts continuous irritation that doesn’t go away.
You would possibly keep in mind a 2004 TIME journal cowl story alerting the general public to the clear hyperlink between irritation and coronary heart illness. That was when elevated CRP was first understood for its function within the growth of power irritation (Rifai and Ridker 2001). It was linked not solely to coronary heart illness, but in addition to diabetes, stroke, metabolic syndrome, and lots of different severe, long-term sicknesses — together with osteoporosis.
There are dozens of research which have checked out CRP ranges in people with low bone density and osteoporosis and so they have discovered a transparent relationship between excessive CRP and weak or skinny bones (Ganesan et al. 2005; de Pablo et al. 2012). Curiously, there was a higher relationship between bone weak spot and CRP than bone density. One examine (Schett et al. 2006) concluded that “hs-CRP stage is a major and impartial danger predictor of non-traumatic fracture. This discovering is in keeping with the speculation of a decent interaction between low-grade irritation and bone turnover.” And the place osteoporosis coexists with different inflammatory situations, like emphysema, CRP highlights that affiliation too (Samaria and Bhatia 2015).
C-Reactive Protein is such an necessary marker that I even embrace it on my Medical Checks for Osteoporosis work up that I give to all my shoppers. You possibly can be taught extra about these assessments and their which means in my Osteo Lab Tests Online Course .
Decreasing elevated CRP ranges
- So now that we all know elevated CRP is a purple flag for each your bones and your cardiovascular well being, what can we do about it? Fortunately, lots of the suggestions I supply for bone well being additionally assist scale back irritation and decrease CRP.
- Eat an Alkaline for Life food plan centered on complete meals and full of colourful fruits, berries, veggies, nuts, and seeds — and darkish chocolate. By doing so, you’ll improve your consumption of antioxidants, equivalent to vitamin C, quercetin dihydrate, alpha lipoic acid, selenium, and curcumin, in addition to the fat-soluble nutritional vitamins A, D, E, and Ok, and necessary minerals equivalent to magnesium.
- Remove sugar, fried and processed meals, and scale back alcohol — all of those encourage irritation.
- Train has been discovered to decrease CRP ranges and strengthen bone on the similar time. Aware workouts like tai chi and yoga will be useful for folks simply beginning out — and so they assist decrease stress ranges, which not surprisingly are additionally related to increased CRP and irritation.
- Relaxation! Getting inadequate sleep has been proven to extend irritation and CRP ranges. (And no, taking a nap received’t do the trick. You want your eight hours at night time.)
I encourage you to be taught extra about conserving your coronary heart and bones wholesome, together with the superb advantages that vitamin K2 provides your coronary heart and your bones. Learn my weblog — Is vitamin K2 your physique’s greatest buddy? — for extra.
Barbour, Ok. E., et al. 2012. Inflammatory markers and the risk of hip fracture: The Women’s Health Initiative. J Bone Mineral Res. 27(5):1167-1176.
de Pablo, P., M. S. Cooper, and C. D. Buckley. 2012. Association between bone mineral density and C‐reactive protein in a large population‐based sample. Arthritis Rheum. 64(8):2624–2631.
Ganesan, Ok., et al. 2005. Relationship of C-reactive protein and bone mineral density in community-dwelling elderly females. J Natl Med Assoc. 97(3):329–333.
He, L. P., et al. 2010. Early C-reactive protein in the prediction of long-term outcomes after acute coronary syndromes: A meta-analysis of longitudinal studies. Coronary heart 96(5):339-346.
Jaffe, R., and J. Mani. 2014. Predictive biomarkers in personalized laboratory diagnosis and evidence based best practices outcome monitoring. Townsend Letter, Jan 2014.
Li, Y. W., et al. 2017. Hs-CRP and all-cause, cardiovascular, and cancer mortality risk: A meta-analysis. Atherosclerosis. 259:75-82.
Rifai, N., and P. M. Ridker. 2001. High-sensitivity C-reactive protein: A novel and promising marker of coronary heart disease. Clin Chem. 47(3):403-411.
Samaria, J. Ok., and M. Bhatia. 2015. Raised CRP levels associated with osteoporosis in patients with COPD. Am J Respir Crit Care Med. 191:A5716.
Schett, G., et al. 2006. High-sensitivity C-reactive protein and risk of nontraumatic fractures in the Bruneck Study. Arch Intern Med. 166(22):2495-2501.
Xu, W. X., et al. 2015. High-sensitivity CRP: Possible link between job stress and atherosclerosis. Am J Ind Med. 58(7):773-779.